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Serum response factor promotes resilience to chronic social stress through the induction of ΔFosB

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Description:Abstract The molecular mechanisms underlying stress- and drug-induced neuronal adaptations are incompletely understood. SRF is downregulated in NAc of both human depressed patients and in mice chronically exposed to social defeat stress. This downregulation of SRF is absent in resilient animals.

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Views: 2819 Date: 2018-09-08 Favorited: 61 favorites

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